The Luna-25 launch is Moscow’s first lunar mission since 1976, when the Soviet Union boasted a pioneering space programme that has lost its shine because of funding problems and corruption.
The launch from the Vostochny Cosmodrome in the Far East is scheduled for 2:11 am Moscow time Friday (2311 GMT Thursday), Russia’s space agency Roscosmos has said.
The four-legged lander weighs around 800 kilogrammes (1,750 pounds) and is set to reach the lunar orbit around five days later.
It is estimated to touch near the Moon’s south pole sometime around August 21, a source at Roscosmos told AFP.
Roscosmos said the module would operate for one year and “take and analyse soil samples and conduct long-term scientific research” on lunar surface material and the atmosphere.
Independent space analyst Vitaly Yegorov said the Luna-25 mission was an important test for Russia’s space programme.
“So the biggest question will be: can it land?”
President Vladimir Putin wants to strengthen cooperation in space with China and scale back partnerships with the West, mirroring Russia’s geopolitical priorities.
Moscow has announced it will end its work with the United States on the International Space Station (ISS) by 2028 and wants to participate in a rival project led by Beijing.
The European Space Agency (ESA) said it would not cooperate with Moscow on the Luna-25 launch — as well as future 26 and 27 missions — after Putin deployed troops in Ukraine last year.
Moscow vowed to go ahead with the mission and replace ESA equipment with Russian-made instruments.
Speaking at the Vostochny Cosmodrome last year, Putin said the Soviet Union had sent the first man to space in 1961 despite a “total” sanction regime.
He said Russia would develop its lunar programme despite Western economic penalties that reached unprecedented levels over the Ukraine conflict.
“We are guided by the ambition of our ancestors to move forward, despite any difficulties and despite external attempts to prevent us from moving,” Putin said.
In June, the head of Roscosmos, Yuri Borisov, described the launch as high-risk.
“This mission involves landing at the south pole. No one in the world has ever done such things,” he said during a meeting with Putin.
Most Moon landings have occurred near the lunar equator.
“These kinds of missions are always risky,” he told the Russian leader, claiming estimates put the chance of success at around 70 percent.
The rocket boosters are predicted to fall in the vicinity of the village of Shakhtinsky in the far-eastern region of Khabarovsk, so the residents of the settlement will be evacuated on Friday morning, local authorities said.
The last Soviet Moon mission in 1976, the Luna 24, brought lunar soil samples back to Earth.
The Soviets launched the first satellite Sputnik, and sent into orbit the first animal, a dog named Laika; the first man, Yuri Gagarin; and the first woman, Valentina Tereshkova.
Russia’s programme, which still relies on Soviet-designed technology, has struggled to innovate and the Kremlin has instead prioritised military spending.
It has also been plagued by corruption scandals and botched launches, and faced competition from the United States and growing Chinese ambitions.